Infections can lead to massive inflammation in the body

It is true that the subject COVID-19 has lost popularity in society, however, the figures reveal that the pandemic is still very active, and in Portugal several people continue to die daily.

Regarding the COVID-19 disease, there is new information. A recent study reveals that COVID-19 infections can lead to massive inflammation in the body.

COVID-19: Infections can lead to massive inflammation in the body

COVID-19: The virus can infect immune system cells called monocytes and macrophages

from the first days of the pandemic that doctors noticed that in severe cases of COVID-19 - those who took people to hospitals connected to ventilators - most internal injuries were not caused directly by the virus itself, but by a wave of triggered immune reactions. the body to fight infection.

A now published study reveals that the SARS-CoV-2 virus, which causes COVID_19, can infect certain types of immune system cells called monocytes and macrophages. Monocytes and macrophages are the first line white blood cells of the immune system. Their task is to circulate in the blood and tissues, to find and destroy pathogens.

When this threat is absorbed, these cells possess what can be described as a “cellular dumping ground” called the endosome, which normally eliminates the infectious agent.

COVID-19: Infections can lead to massive inflammation in the body

Monocytes and macrophages lack ACE-2 receptors, the gates the virus uses to dock and infect other cell types. Instead, the virus enters these cells because of another immune system worker – the Y-shaped antibodies that latch onto the virus in an attempt to prevent it from attaching to our cells.

When the antibodies catch the virus, the tail of the antibody - called the FC part - sticks out. This rod acts as a flag to call monocytes and macrophages to let them know there's a bad guy out there.

According to the study, people with COVID-19 tended to have a more unusual type of monocytes with CD16 receptors. These receptors recognize the antibody stalks the body produces to fight the SARS-CoV-2 virus.

These antibodies bind to monocytes with CD16 receptors, causing the cell to take up the virus. Once inside, the virus begins to try to replicate itself, triggering the harmful inflammatory response.

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